Transcriptional Intermediary Factor 2, Tif-2 (685-697)

This 13-amino acid TIF2 peptide with a LxxLL motif is derived from the NR box2 region of TIF2 (SRC2?). A short consensus motif, so-called nuclear receptor (NR) box, mediates ligand-dependent activation interaction function between nuclear receptors and their coregulators. This TIF2 peptide fragment is sufficient to interact with thyroid hormone ligand binding domain, TR-beta-LBD.